First Parish is located in Wayland's town center, at the intersection of Routes 20 and 27/126.

4.5 miles west of Route 128/95 on Route 20
4.2 miles north of Route 9 on Route 27
1.7 miles east of the Wayland/Sudbury town line
3 miles southeast of Sudbury town center on Route 27

5.5 miles south of Walden Pond on Route 126